Mu TW, Lester HA, Dougherty DA (2003) Different binding orientations for the same agonist at homologous receptors: A lock and key or a simple wedge? J Am Chem Soc, 125: 6850-6851.įeng Y, Liu L, Mu TW, Guo QX (2002) Influence of a hydrophobic enviromment on the structure of arginine-carboxylate salt bridge. Mu TW, Fowler DM, Kelly JW (2008) Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.
Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW (2008) Chemical and biological approaches synergize to ameliorate protein-folding diseases.
Ong DS, Mu TW, Palmer AE, Kelly JW (2010) Endoplasmic reticulum Ca 2+ increases enhance glucocerebrosidase folding, trafficking and function. Ong DS, Wang YJ, Tan YL, Yates JR,* Mu TW,* Kelly JW* (2013) FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher’s disease fibroblasts. Journal of Proteome Research, 12: 5570-5586. Wang YJ, Han DY, Tabib T, Yates JR, Mu TW (2013) Identification of GABA C receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches. PMCID: PMC4169380ĭi XJ, Han DY, Wang YJ, Chance MR, Mu TW (2013) SAHA enhances proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA A receptors. Wang YJ, Tayo BO, Bandyopadhyay A, Wang H, Feng T, Franceschini N, Tang H, Gao J, COGENT consortium, Williams SM, Elston RC, Cooper RS, Mu TW, Zhu X (2014) The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic-reticulum-associated degradation and loss of function. Journal of Biological Chemistry, 290:325-337. Han DY, Di XJ, Fu YL, Mu TW (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic Acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Han DY, Guan BJ, Wang YJ, Hatzoglou M, Mu TW (2015) L-type calcium channel blockers enhance trafficking and function of epilepsy-associated a1(D219N) subunits of GABA A receptors. Journal of Biological Chemistry, 291:9526-9539. PMCID: PMC5720379.ĭi, XJ, Wang, YJ, Han, DY, Fu, YL, Duerfeldt, AS, Blagg, BSJ, Mu, TW (2016) Grp94 protein delivers g-aminobutyric acid (GABA A ) Receptors to Hrd1 protein-mediated Endoplasmic Reticulum-Associated Degradation. PMID: 30481215.ĭawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan Pattabiraman, Raul Jobava, Xiao-Jing Di, Martin Snider, Ting-Wei Mu, Eric Pearlman, Anna Blumental-Perry, and Maria Hatzoglou (2017) GADD34 promotes Golgi apparatus integrity and osmoadaptation of human corneal cells. Yan-Lin Fu, Dong-Yun Han, Ya-Juan Wang, Xiao-Jing Di, Hai-Bo Yu, and Ting-Wei Mu (2018) Remodeling the Endoplasmic Reticulum Proteostasis Network Restores Proteostasis of Pathogenic GABA A Receptors. Biochemical and Biophysical Research Communications. Yan-Lin Fu, Bin Zhang, and Ting-Wei Mu (2019) LMAN1 (ERGIC-53) promotes the trafficking of neuroreceptors. ĭi XJ, Wang YJ, Cotter E, Wang M, Whittsette AL, Han DY, Sangwung P, Brown R, Lynch JW, Keramidas A, Mu TW (2021) Proteostasis regulators restore function of epilepsy-associated GABAA receptors, Cell Chem Biol.
Topisirovic I, Larsson O, Hatzoglou M (2022 ) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, et al. Whittsette AL, Wang YJ, Mu TW (2022) The Endoplasmic Reticulum Membrane Complex Promotes Proteostasis of GABAA Receptors. Wang YJ, Di XJ, Mu TW (2022) Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors. Pharmacologic ATF6 Activation Remodels the Proteostasis Network to Rescue Pathogenic GABAA Receptors. Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW (2022).
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